TL;DR
Gene editing has learned to change one letter of human DNA, inside the body, with a single infusion, and it is working in people. One treatment raised a missing lung-protecting protein above the protective level and is now in the trial stage meant to win approval. Another cut LDL cholesterol by up to 62% in one shot, with the effect lasting up to 18 months so far. A third let patients who must eat every few hours go as long as 15 hours without food. The trials are small and the side effects are real, but the direction is clear: diseases managed with daily pills or nightly cornstarch could become diseases fixed once, at the source.
Below the line, for paid subscribers: The full story: where it stands, how we got here and what's dated next; our Odds board on 5 milestones, starting with "Lilly's VERVE-102 Phase 2 trial begins enrolling by 2026"; our labeled speculation on what it adds up to; and every source.