My A.I. Psychosis

My A.I. Psychosis

Drugmakers Are Now Trying to Wake Sleeping Hair Follicles

Pelage's PP405 began a 600-man, 12-month trial on Oct. 14, and a slow-release minoxidil pill has two positive final-stage trials but no FDA filing date.

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My A.I. Psychosis
Oct 21, 2026
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TL;DR

For decades, treating baldness has meant two moves: block the hormone that shrinks hair follicles, or nudge growth with minoxidil. The new bet is bolder. Several companies now think bald follicles are asleep rather than gone, and they are building drugs to wake them up. The first of those, a cream called PP405, started a 600-man, year-long trial on Oct. 14. Nearer at hand, a slow-release minoxidil pill has passed two final-stage trials, and a company has started injecting people with their own lab-multiplied hair cells. None of it is proven yet. If the waking drugs work, hair loss could shift from something people slow down to something they reverse.

Below the line, for paid subscribers: The full story: where it stands, how we got here and what's dated next; our Odds board on 6 milestones, starting with "Rubedo reports first RLS-1496 hair-loss data by 2027"; our labeled speculation on what it adds up to; and every source.

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