TL;DR
Two ideas about how hearts and arteries age just moved in opposite directions. The first big test of a drug aimed at lipoprotein(a), a cholesterol-carrying particle set mostly by genes and long blamed for clogged arteries, came back a miss: the drug lowered the particle in more than 8,000 heart patients but did not significantly cut heart attacks, strokes or heart deaths. At the same time, a new scientific review argues that aging may start in the body's tiniest blood vessels and spread from there. For people with high Lp(a) and no good treatment, the wait just got longer. For the science of aging, there is a new place to look, though nobody has built a treatment for it yet.
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