TL;DR
Most osteoporosis drugs slow bone loss. The ones that actually build new bone come as daily injections. A company called Entera Bio says it has a tablet that does the same job: in a six-month trial in 161 women, its pill raised spine and hip bone density, with gains the company calls comparable to the injected standard, Forteo. A pill is easier to start and keep taking than a shot, which could mean treating people earlier, before the first broken hip. Meanwhile, a knee-arthritis shot has entered its first human trial, and in old mice, blocking a single aging enzyme regrew real joint cartilage. Nobody has yet rebuilt cartilage in a living human joint, and the bone pill's final trial has no start date.
Below the line, for paid subscribers: The full story: where it stands, how we got here and what's dated next; our Odds board on 5 milestones, starting with "Entera Bio starts its roughly 900-woman EB613 Phase 3 by 2027"; and every source.